The Taft equation is often employed in penicillin allergies.
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A still very interesting application is the Hammett equation, Taft equation and pKa prediction methods.
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The Taft equation is written as:
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This equation is combined with the equation for ? * to give the full Taft equation.
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Taft outlined the application of this method to solving the Taft equation in a 1957 paper.
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When a reaction series is not significantly influenced by polar effects, the Taft equation reduces to:
7.
The "'Taft equation "'is a resonance effects influence reaction rates, the Taft equation also describes the steric effects of a substituent.
8.
The "'Taft equation "'is a resonance effects influence reaction rates, the Taft equation also describes the steric effects of a substituent.
9.
When both steric and polar effects influence the reaction rate the Taft equation can be solved for both ? * and ? through the use of standard least squares methods for determining a bivariant regression plane.